Acute and Subchronic Toxic Effects of the Fruits of Physalis peruviana L.

Table 3

Effect on hematological parameters after oral administration of lyophilized fruit juice of Physalis  peruviana L. during subchronic period in male Wistar rats (𝑛: 7).

	Male
	Control	100 mg kg^−1	1000 mg kg^−1	5000 mg kg^−1
WBC (10^3 μL^−1)	5.54±0.93	5.68±1.28	4.45±0.69	5.30±1.89
Neutrophils (%)	3.27±2.12	4.45±1.54	5.68±1.64	6.08±2.53
Lymphocytes (%)	90.83±9.72	89.53±5.27	85.65±5.33	88.30±4.08
Monocyte (%)	3.63±3.98	3.72±2.20	4.44±2.45	2.39±1.63
Eosinophils (%)	1.54±1.97	1.76±1.42	2.47±1.60	2.59±0.92
Basophils (%)	0.93±0.28	2.27±1.57	0.17±0.10	0.40±0.16
RBC (10^6 μL)	8.14±0.41	7.98±0.56	8.18±0.39	8.03±0.46
HGB (g dL^−1)	15.06±0.50	14.70±1.08	15.40±0.89	14.70±0.53
Haematocrit (%)	43.00±1.41	40.90±3.16	42.77±2.36	47.18±4.09
MCV (fL)	52.89±1.61	51.22±1.60	51.30±1.77	57.39±4.49
MCH (pg)	18.53±0.45	18.38±0.46	18.44±0.40	18.03±0.61
MCHC (g dL^−)	35.01±0.47	35.92±0.30	36.00±0.55	31.57±3.31
RDW-CV (%)	15.03±1.13	16.84±2.21	17.09±1.27	19.40±2.97
Platelet (10^3 μL^−)	717.13±92.93	795.00±75.24	768.33±34.42	918.00±166.35
MPV (fL)	7.49±0.38	7.12±0.40	6.93±0.16	7.30±0.10

WBC: white blood cell; RBC: red blood cell; HGB: haemoglobin; MCV: mean corpuscular volume; MCH: mean corpuscular Hb; MCHC: mean corpuscular Hb conc; RDW-CV: coefficient variation of red cell distribution width; MPV: mean platelet volume.