Mechanism of Hepatoprotective Effect of Boesenbergia rotunda in Thioacetamide-Induced Liver Damage in Rats
Immunohistochemistry staining of PCNA of livers sampled from rats in different experimental groups. (a) Normal livers did not show signs of PCNA expression in hepatocytes from control rats. (b) Cirrhosis control liver showed severe fibrosis with greater PCNA expression in the necrotized hepatocytes. (c) Silymarin-treated liver showed less PCNA-stained hepatocytes (arrow) indicating less hepatocyte proliferation. (d) The low dose BR-treated liver showed moderate hepatocyte proliferation as indicated by moderate PCNA staining (arrow) in the hepatocytes. (e) High dose BR-treated livers showed minor PCNA expression (arrow) with few proliferated necrotized hepatocytes which were observed in the liver (original magnification 40).
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