Reversion of P-Glycoprotein-Mediated Multidrug Resistance in Human Leukemic Cell Line by Diallyl Trisulfide
Figure 4
Morphology observed by light microscopy.
(a) K562/A02 cells grown 48 hours without drugs (400 magnification). Cells proliferated actively, mitotic easy to see (shown with ↑)
(b) K562/A02 cells grown 48 hours with adriamycin (1 ) (400 magnification). Cells proliferated actively, mitotic easy to see (shown with ↑)
(c) K562/A02 cells grown 24 hours with adriamycin and DATS (2 ) (400 magnification). Proliferation of K562/A02 cells slowed down, mitotic rarely to see
(d) K562/A02 cells grown 48 hours with adriamycin and DATS (400 magnification). K562/A02 cells showed cell shrinkage, chromatin condensation, margination, nuclear fragmentation, apoptotic bodies easy to see (shown with ↑)
(e) K562/A02 cells grown 72 hours with adriamycin and DATS (400 magnification). Survival rate of K562/A02 cells reduced, apoptotic bodies easy to see (shown with ↑)