Drug Target Prediction Based on the Herbs Components: The Study on the Multitargets Pharmacological Mechanism of Qishenkeli Acting on the Coronary Heart Disease

Table 3

The depletion analyses of proteins with the highest degree/betweenness centrality among top 0.1% and top 1% candidate target-genes.

	Lower-tailed 𝑃 values of hypergeometric cumulative distribution
	Top 0.1% candidate targets	Top 1% candidate targets
The proteins with the highest degreea	4.97𝐸−07	3.89𝐸−06
The proteins with the highest betweenness centralitya	4.97𝐸−07	3.24𝐸−05

aThe proteins with the highest degree/betweenness centrality are referred to as those with top 5% degree/betweenness centrality in the protein interaction network.