Drug Target Prediction Based on the Herbs Components: The Study on the Multitargets Pharmacological Mechanism of Qishenkeli Acting on the Coronary Heart Disease

Table 2

Significantly enriched GO term among top 0.1% candidate target genes of QSKL compositive compounds.

GO term ID	GO term name	𝑃 valuea
GO:0006520	Cellular amino acid metabolic process	1.99𝐸−13
GO:0009058	Biosynthetic process	4.32𝐸−09
GO:0044281	Small molecule metabolic process	2.55𝐸−08
GO:0034641	Cellular nitrogen compound metabolic process	2.27𝐸−07
GO:0003013	Circulatory system process	1.40𝐸−06
GO:0006399	tRNA metabolic process	6.43𝐸−06
GO:0007267	Cell-cell signaling	1.60𝐸−04
GO:0006950	Response to stress	1.88𝐸−04
GO:0006412	Translation	3.70𝐸−04
GO:0042592	Homeostatic process	4.40𝐸−04
GO:0055085	Transmembrane transport	4.90𝐸−04
GO:0071941	Nitrogen cycle metabolic process	7.37𝐸−04
GO:0007568	Aging	7.90𝐸−04
GO:0006810	Transport	9.10𝐸−04
GO:0050877	Neurological system process	2.35𝐸−03
GO:0006461	Protein complex assembly	1.75𝐸−02
GO:0019748	Secondary metabolic process	1.99𝐸−02
GO:0065003	Macromolecular complex assembly	4.30𝐸−02

aThe top 0.1% candidate target genes are significantly enriched with genes annotated with a GO term when its corresponding upper-tailed 𝑃 value of hypergeometric cumulative distribution is smaller than 0.05. These GO terms are ranked according to the order of the increasing 𝑃 values.