Refined Qingkailing Protects MCAO Mice from Endoplasmic Reticulum Stress-Induced Apoptosis with a Broad Time Window

Figure 7

Effect of RQKL on intracellular Ca²⁺ in brain cells. Mice were divided into five groups: sham group, I2h group for cerebral ischemia 2 h, I2hR10h group suffering ischemia 2 h followed 10 h reperfusion. RQKL therapeutic group received RQKL (3 mL/kg) immediately after ischemia. Neurons of hippocampal and forehead cortex regions were detected by flow cytometry analysis. The results are expressed as mean fluorescence intensity (MFI). Note. ^ΔΔ𝑃<0.01, versus sham, ^Δ𝑃<0.05, versus sham, ^##𝑃<0.01, versus ischemia, 𝑛=6.