Protective Effect of Silymarin against Acrolein-Induced Cardiotoxicity in Mice
Figure 7
Cardiac tissues of vehicle-control mice show normal histological pattern. Hematoxylin and eosin ×400. (a) ACR-treated mice indicate prominent interstitial edema (V) and focal moderate interstitial inflammation (T) in heart tissues. Hematoxylin and eosin ×400. (b) Cardiac sections of mice treated with SN (25, 50, and 100 mg/Kg, i.p.) plus ACR and Vit E plus ACR demonstrate the decrease in damages. Hematoxylin and eosin ×400. ((c), (d), (e), and (f), resp.) Cardiac tissues of animals which were injected with SN (100 mg/Kg) show normal myocardium architecture. Hematoxylin and eosin ×400. (g) Vehicle-control group received normal saline +0.5% w/v methylcellulose, orally for 3 weeks. ACR was given (7.5 mg/kg, orally) for 3 weeks. SN was injected 7 days before ACR and daily thereafter throughout the study (3 weeks). Vit E (100 IU/Kg, three times per week) plus ACR were administrated for 3 weeks. SN alone at dose (100 mg/kg, intraperitoneally) was treated for 4 weeks.
