Activations of Both Extrinsic and Intrinsic Pathways in HCT 116 Human Colorectal Cancer Cells Contribute to Apoptosis through p53-Mediated ATM/Fas Signaling by <i>Emilia sonchifolia</i> Extract, a Folklore Medicinal Plant

<table>A proposed working model for the action and possible signaling pathways of ESE on HCT 116 human colorectal cancer cells. ESE induces apoptosis through both extrinsic and intrinsic apoptotic pathways, resulting from p53-mediated ATM/Fas signaling, which counteracts the induction of apoptotic death in HCT 116 cells (see text for details).</table>

Evidence-Based Complementary and Alternative Medicine

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Figure 7

Figure 7: Activations of Both Extrinsic and Intrinsic Pathways in HCT 116 Human Colorectal Cancer Cells Contribute to Apoptosis through p53-Mediated ATM/Fas Signaling by <i>Emilia sonchifolia</i> Extract, a Folklore Medicinal Plant 

Figure 7 | Activations of Both Extrinsic and Intrinsic Pathways in HCT 116 Human Colorectal Cancer Cells Contribute to Apoptosis through p53-Mediated ATM/Fas Signaling by Emilia sonchifolia Extract, a Folklore Medicinal Plant 