Neuroprotection by the Traditional Chinese Medicine, Tao-Hong-Si-Wu-Tang, against Middle Cerebral Artery Occlusion-Induced Cerebral Ischemia in Rats
Effects of Tao-Hong-Si-Wu-Tang (THSWT) in middle cerebral artery occlusion-(MCAO-) induced focal cerebral ischemia in rats. (a) Coronal sections of 2,3,5-triphenyltetrazolium-(TTC-) stained brains, (b) dose-response effect of THSWT, and (c) the infarct area at various distances from the frontal pole 24 h after MACO-reperfusion rats. Cerebral infarction in sham-operated (sham) or MACO-reperfusion rats is from a representative animal that received the solvent (distilled water) or THSWT (0.7 and 1.4 g ) orally for 14 days. (a) TTC-stained brains and (b) infarct volumes were calculated as described in “Methods”, and data are presented as the infarct volume for each animal in the group as well as the (). , compared to the sham-operated group. (c) Forebrain profiles of the infarct area at various distances from the frontal pole as described in “Methods”. Each point (○, solvent-treated group; Δ, THSWT 0.7 g -treated group) and vertical bar represent the means S.E.M. (). and , compared to the solvent-treated group.
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