Ameliorative Effect of Active Principle Isolated from Seeds of Eugenia jambolana on Carbohydrate Metabolism in Experimental Diabetes
Table 3
Effect on liver and kidney function tests during oral toxicity studies of active principle (LH II) isolated from ethanolic extract of seeds in normal rabbits (1 month treatment).
Parameter
Healthy control
Treated 5 times of effective dose
Treated 10 times of effective dose
Treated 15 times of effective dose
Serum Bilirubin (mg dL−1)
0.45 0.02
0.44 0.03
0.44 0.02
0.44 0.02
SGPT (IU L−1)
11.2 1.1
12.1 1.3
11.5 0.9
11.5 0.9
Serum ALP (U L−1)
33.0 2.4
33.2 3.1
33.0 2.8
33.0 2.8
Serum protein (g dL−1)
8.0 0.9
7.9 0.6
8.0 0.6
8.0 0.2
Blood urea (mg dL−1)
15.0 1.3
15.0 1.7
15.9 1.5
15.4 1.8
Serum Creatinine (mg dL−1)
1.3 0.1
1.4 0.3
1.4 0.1
1.4 0.2
Values are mean SEM for five animals in each group. No significant difference between control and treated groups.
