Radiation-Induced Testicular Injury and Its Amelioration by Tinospora cordifolia (An Indian Medicinal Plant) Extract

Table 1

Variation in body weight, tissue weight, and testes-body weight ratio of mice after exposure to 7.5 Gy gamma radiation with (experimental) or without (irradiated control) TCE. The values represent mean ± S.E. The statistical significance was obtained between normal versus irradiated control and irradiated control versus experimental (𝑃<  * =  .05, ** =  .01, *** =  .001).

Parameter	Group	Posttreatment autopsy intervals
		0 hrs	12 hrs	24 hrs	3 days	7 days	15 days	30 days
Body weight (g)	I	25±4.32	25±5.21	26±4.63	27.18±5.67	28.62±6.21	30.50±6.73	32.78±7.12
	II	24±4.12	26.00±4.21	28.65±6.11	31.33±6.23	33.66±6.11	35.89±5.81	38.66±8.11
	III	24.08±4.82	23.16±5.02	21.39±3.83	19.06±1.51 *	16.58±4.47 *	14.44±5.7 **	N.S.
	IV	24.53±4.27	23.67±4.92	22.69±3.32	20.75±2.9	17.63±4.31	18.73±5.31	21.17±3.35 *
Tissue weight (g)	I	0.159±0.01	0.162±0.05	0.166±0.07	0.175±0.08	0.185±0.09	0.197±0.06	0.213±0.07
	II	0.154±0.02	0.168±0.06	0.187±0.08	0.209±0.09	0.226±0.07	0.245±0.11	0.267±0.12
	III	0.154±0.04	0.146±0.021	0.134±0.032	0.118±0.021 *	0.092±0.001 **	0.016±0.002 **	N.S.
	IV	0.153±0.034	0.153±0.033	0.143±0.31	0.126±0.019	0.094±0.004	0.103±0.011	0.119±0.017
Weight Index	I	0.638±0.05	0.639±0.051	0.642±0.048	0.644±0.043	0.647±0.053	0.649±0.05	0.652±0.07
	II	0.643±0.04	0.649±0.052	0.653±0.047	0.662±0.051	0.672±0.048	0.684±0.050	0.693±0.052
	III	0.639±0.051	0.630±0.048	0.626±0.046	0.619±0.023	0.554±0.053	0.734±0.057	N. S.
	IV	0.623±0.052	0.646±0.048	0.630±0.042	0.607±0.049	0.533±0.034	0.549±0.037	0.562±0.032

N.S.: Not survival, Group I: Normal/Sham-irradiated, Group II: Negative control, Group III: Irradiated Control, Group IV: Experimental.