Black Tea and Theaflavins Assist Healing of Indomethacin-Induced Gastric Ulceration in Mice by Antioxidative Action

Table 1

Dose and day-dependent healing capacities of BT and TF against indomethacin-induced stomach ulceration in mice^𝑎.

Group	Drug dose (mg/kg)	Period of treatment (days)	Macroscopic damage scores (MDS)^b	MDS reduction (%)^c
3rd day-ulcerated untreated	—		3.39±0.24	0
5th day-ulcerated untreated			1.21±0.15
7th day-ulcerated untreated			0.68±0.07
BT-treated	10	3	2.64±0.22^∗	22.13
BT-treated	20	3	1.89±0.17^∗∗	44.25
BT-treated	30	3	1.47±0.15^†	56.64
BT-treated	40	3	0.88±0.06^†,#	74.05
BT-treated	50	3	0.83±0.07^†,#	75.52
BT-treated	40	7	0.55±0.12	83.78
TF-treated	0.5	3	1.12±0.13^†	66.96
TF-treated	1	3	0.81±0.07^†,Ψ	76.4
TF-treated	2.5	3	0.74±0.06^†,Ψ	78.17
TF-treated	4	3	0.62±0.07^†,Ψ	82.3
TF-treated	5	3	0.53±0.06^†,Ψ	84.36
TF-treated	1	7	0.46±0.08	86.44

aStomach ulceration in mice was induced by oral administration of indomethacin (18 mg/kg). Different doses of BT and TF were used for these experiments. bThe MDS were measured on the 3rd, 5th, and 7th day after indomethacin administration and the values are mean ± S.E.M of three independent experiments, each with 5 mice/group. cConsidering a MDS value of 100 for the 3rd day untreated mice. ^∗𝑃<0.05, ^∗∗𝑃<0.01, ^†𝑃<0.001 compared to ulcerated mice; ^#𝑃<0.05 compared to BT (30 mg/kg) treatment; ^Ψ𝑃<0.05 compared to TF (0.5 mg/kg) treatment.