Memory Impairment following Acute Tricyclic Antidepressants Overdose
Table 1
Memory score of TCA-poisoned patients in terms of different parameters at the time of initial consciousness† and 24 hours afterward (mean ± SD) ().
Parameter
Category
Initial consciousness
24 hours after consciousness
Memory score
value
Memory score
value
Gender
Male
22
29.97 ± 9.40
0.36*
49.79 ± 9.89
0.60*
Female
45
32.14 ± 8.83
51.03 ± 8.78
Age range
20–24 yrs
45
32.80 ± 8.50
0.11**
52.48 ± 8.90
0.002**
25–34 yrs
14
30.32 ± 9.60
47.85 ± 8.10
35–44 yrs
5
26.90 ± 6.0
47.50 ± 2.10
45–54 yrs
2
30.75 ± 8.83
49.0 ± 8.40
55–64 yrs
1
9.0 ± 0.0
24.50 ± 0.0
Severity
Mild-to-moderate
52
32.31 ± 8.94
0.13***
46.30 ± 8.50
0.03***
Severe
15
28.36 ± 8.93
51.85 ± 8.90
Dosage range
100–500 mg
42
34.71 ± 7.40
<0.001**
53.48 ± 8.10
<0.001**
501–1000 mg
7
34.37 ± 8.50
53.62 ± 8.50
>1000 mg
18
21.94 ± 5.80
42.10 ± 6.10
Total
67
31.43 ± 9.02
50.62 ± 9.12
<0.001****
†When the patients were awake and were able to communicate after admission. *Independent samples -test; **Pearson correlation test; ***Spearman correlation test; ****paired-samples -test.
