Depression Research and Treatment / 2011 / Article / Tab 2 / Review Article
Dysthymia and Apathy: Diagnosis and Treatment Table 2 Possible medications for apathy.
Category Class Main background disease Representative drug name Antidepressants
SNRIs** NaSSAs*** DNRIs**** Tetracyclic antidepressants Tricyclic antidepressantsDepression Fluvoxamine, Paroxetine Sertraline Milnacipran Mirtazapine Bupropion Maprotiline Amoxapine Nortriptyline Dopamine stimulants Dopamine agonists Parkinson’s disease, depression (?) Bromocriptine Pramipexrole Ropinirole Amantadine MAO-B inhibitor Selegiline Antipsychotic agents Atypical antipsychotic agents Negative symptoms (apathy-like symptoms) of schizophrenia Clozapine, Risperidone, Olanzapine, Quetiapine, Ziprasidone Psychostimulants Dopaminergic agents Primary apathy or apathy syndrome Methylphenidate Pemoline Amphetamine Modafinil Antidementia agents Cholinesterase inhibitors Alzheimer’s disease Donepezil Galantamine Rivastigmine Metrifonate Tacrine Pyrrolidone-type nootropic agent Stroke, Alzheimer’s disease Nefiracetam Cerebral circulation and metabolism stimulants Ergot alkaloid Stroke Nicergoline Antiplatelet drugs Phosphodiesterase inhibitor Cilostazol
*Selective serotonin reuptake inhibitors: there have been a few reports that SSRIs are not effective for apathy. **Serotonin-noradrenaline reuptake inhibitors. ***Noradrenergic and specific serotonergic antidepressants. ****Noradrenaline-dopamine reuptake inhibitors.