Differential Expression of Claudin 1 and 4 in Basal Cell Carcinoma of the Skin

Figure 4

Immunohistochemical results for claudin 1 (c and f) and claudin 4 (d and g) and corresponding HE-stained sections (b and e) of micronodular BCC (case 1). (a) Micronodular pattern is observed in at low magnification in HE-stained section. (b) BCC cells display adenoid cystic architecture in some areas. In these areas, neoplastic cells are negative for claudin 1 (c) and positive for claudin 4 (d). (e) BCC cells show infiltrative growth arranged in a trabecular pattern in deep areas. In these areas, neoplastic cells are also negative for claudin 1 (f) and positive for claudin 4 (g). (h) Reactivity for claudin 4 is observed in the membrane and cytoplasm.

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