Differential Expression of Claudin 1 and 4 in Basal Cell Carcinoma of the Skin

Figure 3

Representative results for claudin 4 (b, d, f, and h) and corresponding HE-stained sections (a, c, e, and g) in normal skin and lower-grade BCC. (a) Microphotograph of normal epidermis. (b) Cytoplasm of epithelia in the granular layer appears positive. (c, e, and g) microphotographs of HE-stained sections in BCC. (c) Neoplastic cells appear uniformly negative. (d) Reactivity is observed in neoplastic cells with differentiation towards the keratinizing layer. (e) Positivity is limited to neoplastic cell showing follicular differentiation (arrow).

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