The Association between Adiponectin Single Nucleotide Polymorphisms and Side Effects of Isotretinoin in Acne Patients
Table 4
Means and standard deviations of biochemical parameters (baseline, after treatment, and percentage of change by treatment) for the genotype of rs1501299.
Parameter
Genotypes
value
GG, mean (SD)
GT, mean (SD)
HDL (mmol/L)
Baseline
1.42 (0.366)
1.453 (0.358)
0.690
After treatment
1.29 (0.305)
1.35 (0.322)
0.574
% change by treatment
−8.2% (13.5)
−5.6% (18.6)
0.0076
LDL (mmol/L)
Baseline
2.33 (0.598)
2.36 (0.779)
0.082
After treatment
2.80 (0.684)
2.85 (0.826)
0.217
% change by treatment
22.3% (23.5)
24.2% (25.8)
0.709
TChol (mmol/L)
Baseline
4.11 (0.868)
4.24 (0.959)
0.333
After treatment
4.60 (0.874)
4.75 (1.045)
0.216
% change by treatment
13.8% (17.1)
13.3% (15.2)
0.869
TG (mmol/L)
Baseline
0.99 (0.56)
0.99 (0.63)
0.395
After treatment
1.25 (0.68)
1.36 (0.74)
0.572
% change by treatment
36.7% (64.7)
49.7% (62.9)
0.767
AST (U/I)
Baseline
19.15 (5.26)
18.85 (6.88)
0.456
After treatment
21.54 (6.99)
21.39 (8.39)
0.618
% change by treatment
15.3% (36.2)
15.9% (31.4)
0.808
ALT (U/I)
Baseline
15.56 (6.20)
16.30 (9.85)
0.093
After treatment
16.73 (7.69)
18.17 (12.45)
0.268
% change by treatment
12.8% (47.6)
18.0% (47.6)
0.819
∗Student’s t-test was used. P value is significant at less than 0.05. HDL: high-density lipoprotein. LDL: low-density lipoprotein. TChol: total cholesterol. AST: aspartate aminotransferase. ALT: alanine aminotransferase.
