The Association between Adiponectin Single Nucleotide Polymorphisms and Side Effects of Isotretinoin in Acne Patients

Table 2

Alterations in lipid profile and liver transaminases after use of oral isotretinoin.

Parameter	Reference value	Baseline, mean (SEM)	After treatment, mean (SEM)	value
HDL (mmol/L)	0.9–1.5	1.44 (0.02)	1.31 (0.02)	≤0.001
LDL (mmol/L)	2.6–4.8	2.35 (0.04)	2.82 (0.05)	≤0.001
TChol (mmol/L)	Up to 5.2	4.17 (0.06)	4.68 (0.06)	≤0.001
Triglycerides (mmol/L)	Up to 4.8	0.99 (0.04)	1.30 (0.05)	≤0.001
ALT (U/L)	Up to 41	15.91 (0.54)	17.43 (0.68)	0.007
AST (U/L)	Up to 35	19.01 (0.40)	21.47 (0.51)	≤0.001

Data were obtained from the paired t-test. Correlation is significant at p value less than 0.05. SEM: standard error of the mean. HDL: high-density lipoprotein. LDL: low-density lipoprotein. TChol: total cholesterol. AST: aspartate aminotransferase. ALT: alanine aminotransferase. Laboratory normal reference value of lipid profile and liver enzymes. Source: Biochemistry Laboratory of Jordan University of Science and Technology, Health Center, Irbid.