Two Functional TP53 Genetic Variants and Predisposition to Keloid Scarring in Caucasians

Table 1

Association analysis of two TP53 gene polymorphisms with keloid in Caucasians.

Polymorphism^a (position)	Allele^b; (1/2)	Cases; 1/2 (%)	Controls; 1/2 (%)		Cases (n = 86)			Controls (n = 100)				OR (95% CI)^d
					11	12 (%)	22	11	12 (%)	22
rs1042522 (chr. 17: 7579472)	G/C	137/35 (80/20)	143/57 (72/28)	0.690	54 (63)	29 (34)	3 (3)	51 (51)	41 (41)	8 (8)	0.070	0.63 (0.39–1.04)
rs17878362 (chr. 17: 7579690)	A1/A2	152/20 (88/12)	172/28 (86/14)	0.496	67 (78)	18 (21)	1 (1)	73 (73)	26 (26)	1 (1)	0.485	0.80 (0.42–1.51)

^aSNP position was indexed to the NCBI build 37 (GRCh37.p13). ^bAllele 1 and allele 2 were defined as the nonsusceptible allele or the risk allele, respectively. values for logistic regression in additive mode of inheritance of the risk allele. ^dORs and CIs were calculated using the nonsusceptible allele as a reference.