Loss of the Desmosomal Component Perp Impairs Wound Healing In Vivo
Figure 4
Migrating keratinocytes display reduced desmosomal protein expression at the wound edge. (a)–(d) Immunofluorescence images of Perp expression in the epithelium at different timepoints post wounding in control mice. The dashed yellow line represents the border between the migrating keratinocytes and underlying dermis. (e)–(h) Desmoglein 3/1 expression at different timepoints post wounding in control mice (tamoxifen-injected mice). (i)–(l) Immunofluorescence images of Perp expression in the epithelium at different timepoints post wounding in K14CreER; mice. (m)–(p) Desmoglein 3/1 expression at different timepoints post wounding in K14CreER; mice. DAPI is used to mark nuclei. Arrows indicate cells with reduced desmosomal protein staining. Scale bar in (a) equals , scale bar in (b) equals , and scale bar in (c) equals .
