Loss of the Desmosomal Component Perp Impairs Wound Healing In Vivo
Figure 3
Wounded K14CreER; mice exhibit delays in reepithelialization. (a) Cartoon sketch depicting the different stages occurring during the wound healing process. The black dashed line marks the boundary between the epidermis and dermis. Black dashed box demarcates region with migrating keratinocytes, as shown in panel (c). Red dashed box represents region of fully closed wound, as shown in panel (d). EP signifies epidermis and D, dermis. (b) Representative H&E-stained section of open wounds from tamoxifen-injected control () and K14CreER; mice 1 day post wounding. (c) Representative H&E-stained section of wounds from tamoxifen-injected control () and K14CreER; mice 5 days post wounding. The migrating epithelial sheets are outlined by the black dashed line. (d) Representative H&E-stained section of closed wounds from tamoxifen-injected control () and K14CreER; mice 10 days post wounding. Sizes of boxes in (b) and (c) were determined by the edges of the wound, as marked by the panniculus carnosus.
