Disease Markers / 2023 / Article / Tab 2 / Review Article
Meta-Analysis of Assessment of Total Oxidative Stress and Total Antioxidant Capacity in Patients with Periodontitis Table 2 The mean values of TOS in various biological fluid samples between healthy controls and patients with periodontitis in the included studies of quantitative synthesis.
Study name Country Study design Criteria Age years case/control mean ± SD or range Sample type Unit of measurement Periodontitis Control p -ValueMean ± SD or median (upper–lower value) Sample size (M/F) Mean ± SD median (upper– lower value) Sample size (M/F) Akalın et al. [9 ] Turkey CC Armitage [47 ] 40.66 ± 5.31/38.5 ± 6.10 Serum µ mol22.5 ± 17.21 36 (19/17) 13.77 ± 2.381 28 (13/15) <0.05 Saliva µ mol6.03 ± 1.37 4.16 ± 0.63 <0.05 GCF µ mol39.2 ± 5.95 31.4 ± 5.54 <0.05 Wei et al. [16 ] China PS Armitage [47 ] 40.1 ± 7.3/42.1 ± 7.7 Serum mmol 24.8 ± 18.53 48 (27/21) 19.21 ± 16.246 35 (19/16) <0.05 Saliva mmol 9.12 ± 1.77 6.75 ± 1.02 <0.05 GCF mmol 50.9 ± 6.33 42.76 ± 7.94 <0.05 Esen et al. [19 ] Turkey CS AL ≥ 4 mm and PPD ≥ 5 mm 42.85 ± 9.6/40.05 ± 9.8 Serum µ mol H2 O2 equiv./l7.115 (4.920– 8.055) 20 (4/16) 6.935 (5.655– 8.755) 20 (4/16) 0.920 GCF 0.285 (0.070–0.360) 0.010 (0.010– 0.415) 0.030 Toker et al. [21 ] Turkey Interventional study CAL > 30% of sites; PPD ≥ 5 mm 38.7 ± 5.9/38.0 ± 7.2 GCF µ mol H2 O2 Eq/l10.06 ± 0.22 15 (7/8) 10.4 ± 0.48 10 (6/4) <0.05 Akpinar [22 ] Turkey Interventional Armitage [47 ] 37.7 ± 5.9/37.0 ± 7.4 GCF µ mol H2 O2 equiv./l(9.4–10.7) 10 15 (7/8) (9.7–11.3) 10.6 10 (5/5) Sezer [24 ] Turkey CS – 45.50 ± 7.50/40.75 ± 10.26 Serum µ mol H2 O2 Eq/l19.48 ± 7.91 20 (6/14) 21.47 ± 7.39 20 (6/14) Baltacıoğlu et al. [26 ] Turkey CS and CC Armitage [47 ] 32.55 ± 5.32/30.10 ± 4.06 Serum µ mol16.8 ± 2.467 33 (16/17) 13.77 ± 0.567 30 (16/14) <0.05 Saliva µ mol6.27 ± 0.844 4.167 ± 0.444 <0.05 GCF µ mol H2 O2 Eq/l27.5 ± 4.96 30 19.75 ± 3.46 28 <0.05 Bostanci [27 ] Turkey Interventional studies Armitage [47 ] 38.80 ± 4.87/37.33 ± 5.67 GCF µ mol H2 O2 Eq/l9.74 (8.75–12.25) 15 (6/9) 5.25(4.05–7.72) 15 (7/8) <0.05 Serum 4.2 (3.25–6.85) 3.86(2.24–5.25) >0.05 Kose et al. [28 ] Turkey Comparative study Armitage [47 ] 27–51 years Serum µ mol H2 O2 Eq/l16 ± 4.01 22 (11/11) 12.19 ± 2.77 22 (12/10) <0.05 Saliva 6.8 ± 3.49 4.41 ± 1.54 <0.05 Vincent et al. [42 ] India Comparative study Armitage [48 ] 25–65 years GCF µ mol/l9.08 ± 3.7 20 (10/10) 5.2 ± 1.3 20 (11/9) <0.001
The method utilized for the assessment of TOS values in various biological samples was Erel [
53 ]. SD, standard deviation; Cont, control; H
2 O
2 , hydrogen peroxide; Eq, equivalent; CC, case–control; PS, prospective study; CS, cross-sectional study.
