Correlation Analysis of Prognostic Gene Expression, Tumor Microenvironment, and Tumor-Infiltrating Immune Cells in Ovarian Cancer

Figure 8

(a) Scatter plots illustrating the correlation between CD3E expression and 11 TIC-type proportions (). Each plot’s blue line represents a fitted linear model that shows the immune cell’s proportional tropism and CD3E expression. For correlation testing, the Pearson coefficient was used. Using difference and correlation analyses on violin and scatter plots, 11 TIC types are shown to be correlated with CD3E expression. (b) Scatter plots illustrating the correlation between CD3G expression and 12 TIC-type proportions (). Each plot’s blue line represents a fitted linear model that shows the immune cell’s proportional tropism and CD3G expression. For correlation testing, the Pearson coefficient was used. Using difference and correlation analyses on violin and scatter plots, 10 TIC types are shown to be correlated with CD3G expression. (c) Scatter plots illustrating the correlation between CD3D expression and 11 TIC-type proportions (). Each plot’s blue line represents a fitted linear model that shows the immune cell’s proportional tropism and CD3D expression. For correlation testing, the Pearson coefficient was used. By means of difference and correlation analyses on violin and scatter plots, 10 TIC types are shown to be correlated with CD3D expression. (d) Scatter plots illustrating the correlation between CD2 expression and 12 TIC-type proportions (). Each plot’s blue line represents a fitted linear model that shows the immune cell’s proportional tropism and CD2 expression. For correlation testing, the Pearson coefficient was used. Using difference and correlation analyses on violin and scatter plots, 11 TIC types are shown to be correlated with CD2 expression. (e) Scatter plots illustrating the correlation between CCL19 expression and 11-TIC type proportions (). Each plot’s blue line represents a fitted linear model that shows the immune cell’s proportional tropism and CCL19 expression. For correlation testing, the Pearson coefficient was used. Using difference and correlation analyses on violin and scatter plots, 10 TIC types are shown to be correlated with CCL19 expression. (f) Scatter plots illustrating the correlation between IL2RG expression and the proportion of 12 TIC types (). Each plot’s blue line represents a fitted linear model that shows the immune cell’s proportional tropism and IL2RG expression. For correlation testing, the Pearson coefficient was used. By means of difference and correlation analyses on violin and scatter plots, 10 TIC types are shown to be correlated with IL2RG expression.

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