Research Article

Aldolase A Promotes Colorectal Cancer Progression through Targeting COPS6 and Regulating MAPK Signaling Pathway

Figure 2

Knockdown ALDOA inhibited proliferation and metastasis of CRC cells in vitro. (a, b) The qRT-PCR and western blotting analyses were used to test the knockdown efficiency of ALDOA. (c) Knockdown of ALDOA suppressed proliferation activity of SW480 and DLD1 cells using CCK-8 assays. (d) EdU assays showed that CRC cell proliferation was inhibited by knockdown ALDOA. (e) ALDOA shRNA inhibited CRC cell migration according to wound healing assays. (f) Transwell assays, with Matrigel or not, were applied to assess the capability of CRC cells on invasion and migration. , , and .
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