Loss of WNK1 Suppressed the Malignant Behaviors of Hepatocellular Carcinoma Cells by Promoting Autophagy and Activating AMPK Pathway

Figure 1

WNK1 was highly expressed in HCC cell lines and promoted cell growth. (a, b) WNK1 expression was significantly increased in HCC cell lines. (c, d) The treatment of si-WNK1 or si-WNK2 obviously reduced WNK1 expression. (e) The relationship between WNK1 and PCNA was analysed by GEPIA website. (f, g) Loss of WNK1 significantly reduced the OD values of Huh7 and Hep3B cells. (h–j) Loss of WNK1 reduced the number of clones in Huh7 and Hep3B cells. vs. si-con.

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