Tanshinone IIA Improves Acute Gouty Arthritis in Rats through Regulating Neutrophil Activation and the NLRP3 Inflammasome

Figure 2

TIIA decreases UA, cytokine, or chemokine production in serum and neutrophils in vitro. (a–g) ELISA analyses of serum UA, XOD, IL-6, TNF-α, IL-8, CXCL1, CXCL2, S100A8A9, IL-1β, IL-18, and IL-1RA expressions in the MSU-induced AGA rats (). (h, i) QRT-PCR analyses of IL-1β, IL-6, TNF-α, CXCL1, and CXCL2 mRNA levels in neutrophils in vitro (n =6). ^# and ^##, when compared to the control; and , when compared to the AGA.

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