Transcription Factors Leading to High Expression of Neuropeptide L1CAM in Brain Metastases from Lung Adenocarcinoma and Clinical Prognostic Analysis

Figure 2

Potential upstream regulatory targets of L1CAM and single-cell analysis. Predicted potential upstream transcriptional regulators of L1CAM in LUAD based on Gene Regulatory Network database (GRNdb) (a). Heat map analysis of the correlation of the predicted transcription factors with L1CAM expression in the TCGA-LUAD dataset (b). Correlation of these transcription factors with L1CAM expression in the GSE131907 LUAD brain metastasis malignancy cell dataset (c). Analysis of the proportion of L1CAM-positive cells in LUAD (d) and LUAD cerebrovascular metastases (e). Correlation analysis of L1CAM expression and selected transcription factors ETS1, FOSL2, and STAT1 (f). Survival curves for the relationship between high and low transcription factor expressions and LUAD overall survival (g–i): ETS1 (g), FOSL2 (h), and STAT1 (i).

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