Nonalcoholic Fatty Liver Disease-Associated Liver Fibrosis Is Linked with the Severity of Coronary Artery Disease Mediated by Systemic Inflammation
Table 4
Mediation of inflammation markers on the association between NAFLD fibrosis and Gensini score.
(a)
Association of inflammation markers and HDL with FIB-4
Mediated association with Gensini score
Bootstrapped confidence intervals for the relative indirect effect on Gensini score
SE
value
SE
value
SE
Boot LLCI
Boot ULCI
Model with neutrophil as a mediator
Constant
i1
4.243
0.120
<0.001
i2
6.916
1.541
<0.001
FIB-4
0.377
0.045
<0.001
4.749
0.581
<0.001
1.286
0.356
0.696
2.080
Mediation of neutrophil
3.416
0.540
<0.001
Model with lymphocyte as a mediator
Constant
i1
2.235
0.042
<0.001
i2
5.293
3.886
0.173
FIB-4
-0.072
0.016
<0.001
4.749
0.581
<0.001
-0.053
0.143
-0.370
0.205
Mediation of lymphocyte
0.726
1.596
0.649
Model with monocyte as a mediator
Constant
i1
0.509
0.011
<0.001
i2
-5.664
3.308
0.088
FIB-4
0.008
0.004
0.056
4.749
0.581
<0.001
0.204
0.147
-0.052
0.530
Mediation of monocyte
24.725
5.779
<0.001
Model with NLR as a mediator
Constant
i1
2.013
0.133
<0.001
i2
3.851
1.831
0.036
FIB-4
0.442
0.050
<0.001
4.749
0.581
<0.001
0.674
0.367
0.112
1.542
Mediation of NLR
1.523
0.500
0.002
(b)
Association of inflammation markers with APRI
Mediated association with Gensini score
Bootstrapped confidence intervals for the relative indirect effect on Gensini score‡
SE
value
SE
value
SE
Boot LLCI
Boot ULCI
Model with neutrophil as a mediator
Constant
i1
4.396
0.106
<0.001
i2
-5.845
2.746
0.034
APRI
1.063
0.122
<0.001
12.227
1.584
<0.001
3.692
1.074
1.950
6.147
Mediation of neutrophil
3.474
0.546
<0.001
Model with lymphocyte as a mediator
Constant
i1
2.182
0.038
<0.001
i2
9.237
3.744
0.014
APRI
-0.155
0.043
<0.001
12.227
1.584
<0.001
-0.013
0.302
-0.683
0.563
Mediation of lymphocyte
0.085
1.595
0.957
Model with monocyte as a mediator
Constant
i1
0.506
0.010
<0.001
i2
-2.079
3.265
0.525
APRI
0.037
0.012
0.002
12.227
1.584
<0.001
0.834
0.408
0.203
1.804
Mediation of monocyte
22.754
5.867
<0.001
Model with NLR as a mediator
Constant
i1
2.250
0.120
<0.001
i2
5.691
1.769
0.001
APRI
1.133
0.137
<0.001
12.227
1.584
<0.001
1.880
0.986
0.352
4.144
Mediation of NLR
1.659
0.498
<0.001
Boot LLCI/ULCI: bootstrapped B value lower level (LL) or upper level (UL) confidence interval (CI) for the test of mediation, based on 5,000 bootstrap samples. Unstandardized coefficients and standard error (SE) are reported. ‡The relative indirect effect is statistically different from zero if the confidence intervals do not include zero.
