Research Article
miR-1291 Functions as a Potential Serum Biomarker for Bullous Pemphigoid
Table 1
Characteristics of the BP patients and the healthy controls in the qPCR-based array and qPCR validation studies.
| | qPCR-based array study | qPCR validation study | | BP patients () | HCs () | BP patients () | HCs () |
| | Age (years) median (IQR) | 72.5 (60.75-81.75) | 38.5 (30-54) | 73 (61-82) | 48.5 (42-55) | | Sex (female/male) | 12/8 | 16/4 | 20/25 | 26/34 | | Disease duration (months) median (IQR) | 2 (0.62-3.5) | NA | 2 (1-3.5) | NA | | Previous history, (%) | 7 (35) | 0 | 17 (37.78) | 0 | | Hypertension, | 2 | 0 | 14 | 0 | | Cerebrovascular disease, | 7 | 0 | 9 | 0 | | Mucosal involvement, (%) | 2 (10) | 0 | 10 (22.22) | 0 | | Positive IIF, (%) | 16 (80) | NA | 36 (80) | NA | | Anti-BP180 (U/mL) | | | | | | >9, (%) | 16 (80) | NA | 38 (84.44) | NA | | Anti-BP230 (U/mL) | | | | | | >9, (%) | NA | NA | 25 (55.56) | NA | | CCL17 (pg/mL) median (IQR) | NA | NA | 1368 (410-2088) | 248.5 (143.4-376.7) | | miR-1291 (2-ΔCt), median (IQR) | 1.01 (0.33-2.03) | 0.25 (0.07-0.51) | 0.31 (0.13-0.89) | 0.06 (0.05-0.12) |
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BP: bullous pemphigoid; qPCR: quantitative polymerase chain reaction; HCs: healthy controls; IQR: interquartile ranges; NA: not available.
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