Research Article
In Silico Identification of New Targets for Diagnosis, Vaccine, and Drug Candidates against Trypanosoma cruzi
Table 7
Molecular docking studies of all 6 drug target proteins.
| | Compound name | Compound PubChem ID | AutoDock Vina binding affinity | No. of H-bond/interacted residues |
| | RNA editing complex protein M18 | | Diospirin | CID308140 | -7.5 | 2/GLU89, SER140 | | Hypothetical protein TCDM_03925 | | (1R)-1,6,6-Trimethyl-1,2,7,8-tetrahydronaphtho[1,2-g][1]benzofuran-9,10,11-trione | CID9995530 | -7.9 | 2/ARG641 | | Inosine-guanine nucleoside hydrolases | | Emodin | CID3220 | -9.6 | 5/ASP15, TRP60, ASN40 | | Mitochondrial RNA-binding protein 1 | | (1R)-1,6,6-Trimethyl-1,2,7,8-tetrahydronaphtho[1,2-g][1]benzofuran-9,10,11-trione | CID9995530 | -9.1 | 4/THR45, GLN60 | | Calpain-like cysteine peptidase | | Usambarensine | CID5281413 | -7.3 | 1/GLU42 | | Trans-sialidase | | Usambarensine | CID5281413 | -9.4 | 1/THR155 |
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