A Systematic Review and Meta-Analysis for the Association of Gene Polymorphisms in RAN with Cancer Risk

Table 2

The genotype frequency distribution of RAN SNPs in enrolled studies.

Ref. no.	Year	Cancer type	SNP^a	Sample size			Case			Control			Included in meta-analysis
				Case	Control	Wild homozygote	Heterozygote	Variant homozygote	Wild homozygote	Heterozygote	Variant homozygote
1	2008	Bladder cancer	rs14035 C>T	746	746	348	329	58	318	351	63	0.013	No^b
2	2008	RCC	rs14035 C>T	279	278	143	110	23	129	125	24	0.415	Yes
3	2010	Lung cancer	rs14035 C>T	100	100	65	23	5	52	33	5	0.937	Yes
4	2012	HCC	rs14035 C>T	560	560	376	160	24	390	160	10	0.162	Yes
			rs3803012 A>G	560	560	508	52	0	512	48	0	0.289	Yes
5	2012	HNC	rs3803012 A>G	397	900	344	45	2	799	91	2	0.725	Yes
6	2013	HCC	rs3803012 A>G	1300	2688	1158	95	3	2450	227	1	0.066	Yes
7	2013	Cervical cancer	rs3803012 A>G	1486	1549	1325	141	5	1397	129	3	0.990	Yes
8	2013	Breast cancer	rs3809142 C>T	1792	1867	602	232	28	615	239	32	0.149	No^c
			rs3803012 A>G	1792	1867	766	92	12	772	107	5	0.539	Yes
			rs7301722 C>A	1792	1867	881	733	131	966	716	174	0.015	No^b/c
9	2015	CRC	rs14035 C>T	408	400	267	128	13	233	150	17	0.240	Yes
10	2015	Larynx cancer	rs14035 C>T	135	170	73	32	5	67	93	10	0.002	No^b
11	2016	HCC	rs14035 C>T	147	229	98	42	7	137	69	3	0.080	Yes
12	2017	HCC	rs3803012 A>G	312	320	250	56	6	260	55	5	0.298	Yes

Note: RCC, renal cell carcinoma; HCC, hepatocellular carcinoma; HNC, head and neck cancer; CRC, colorectal cancer; , Hardy-Weinberg equilibrium in the control group. ^aAncestral alleles were referenced in NCBI database. ^bExcluded due to not being in accordance with HWE. ^cExcluded due to the limited number of this locus. The results are in italics if .