TRPV2: A Cancer Biomarker and Potential Therapeutic Target

Figure 2

TRPV2 regulation is involved in cellular responses relevant to cancer. In unstimulated cells, the majority of TRPV2 resides in the endoplasmic reticulum and (early) endosomal compartments, while a minor fraction of the channel is present at the cell surface. Upon stimulation of the cells with a phosphatidylinositol 3-kinase- (PI3K-) activating ligand, the vesicular transport of TRPV2 is increased between intracellular compartments and plasma membrane. Subsequently, the increase in TRPV2-mediated Ca²⁺ entry leads to activation of signaling pathways involved in cellular processes (e.g., survival, apoptosis, proliferation, differentiation, and migration/metastasis). When stimulation is terminated, TRPV2 is recycled back to the intracellular compartments via an endocytic pathway. PM: plasma membrane; ER: endoplasmic reticulum.