TRPV2: A Cancer Biomarker and Potential Therapeutic Target

Figure 1

TRPV2 gene and protein structural organization. (a) Schematic representation of human TRPV2 and neighboring genes on the shorter arm of chromosome 17. UBB: ubiquitin B; FTLP12: ferritin light chain pseudogene 12; C17orf76-AS1: C17orf76 antisense RNA 1. (b) The monomeric structure of TRPV2 contains 761 amino acids, six transmembrane spanning domains (TM), and a pore helix region located between TM5 and TM6. Both N- and C-termini are cytosolic with the N-terminal having a hydrophobic domain (HD) and 6 ankyrin repeats (AR).

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