Construction of an Immune-Associated Gene-Based Signature in Muscle-Invasive Bladder Cancer

Figure 4

Survival analyses of the IAG-based signature in MIBC. Kaplan-Meier curves revealed that the high-risk score was closely associated with poor overall survival (OS) (a), progression-free survival (PFS) of MIBC patients (b), and disease-free survival (DFS) of MIBC patients (c). The ROC curves showed that AUCs for the signature risk score, grade, age, gender, pathologic stage, pathologic M, pathologic N, pathologic T, and subtype were 0.695, 0.551, 0.546, 0.409, 0.649, 0.523, 0.632, 0.598, and 0.381, respectively (d). Univariate Cox regression analysis showed that age, pathologic stage, pathologic T, pathologic M, subtype, and risk score were associated with the OS of MIBC patients (e). Multivariate Cox regression analysis indicated that the IAG-based signature risk score was an independent prognostic factor for MIBC (f).

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