Research Article
Genetic Variability of Antioxidative Mechanisms and Cardiotoxicity after Adjuvant Radiotherapy in HER2-Positive Breast Cancer Patients
Table 3
Association of polymorphisms in antioxidative genes with NT-proBNP levels.
| SNP | Genotype | NT-proBNP median (25-75%) | P | NT-proBNP <125 ng/l, (%) | NT-proBNP ≥125 ng/l, (%) | OR (95% CI) | | OR (95% CI)adj | |
| PON1 rs854560 | AA | 126 (59-200) | | 21 (50.0) | 21 (50.0) | Reference | | Reference | | AT+TT | 79 (51-125) | 0.048 | 44 (74.6) | 15 (25.4) | 0.34 (0.15-0.79) | 0.012 | 0.35 (0.15-0.83) | 0.017 | PON1 rs662 | AA | 79 (47.75-118.5) | | 43 (79.6) | 11 (20.4) | Reference | | Reference | | AG+GG | 135 (60-193) | 0.007 | 22 (46.8) | 25 (53.2) | 4.44 (1.85-10.66) | 0.001 | 5.41 (2.12-13.78) | <0.001 | GSTP1 rs1138272 | CC | 92 (58-156) | | 53 (63.9) | 30 (36.1) | Reference | | Reference | | CT+TT | 78.5 (36-165.5) | 0.407 | 12 (66.7) | 6 (33.3) | 0.88 (0.30-2.56) | 0.821 | 0.71 (0.23-2.16) | 0.545 | GSTP1 rs1695 | GG | 122 (65.75-174.5) | | 24 (54.5) | 20 (45.5) | Reference | | Reference | | GA+AA | 77 (48.5-144) | 0.101 | 41 (71.9) | 16 (28.1) | 0.47 (0.21-1.07) | 0.073 | 0.36 (0.15-0.88) | 0.026 | CAT rs1001179 | GG | 88 (52.5-148.25) | | 42 (65.6) | 22 (34.4) | Reference | | Reference | | GA+AA | 96 (56-182) | 0.680 | 23 (62.2) | 14 (37.8) | 1.16 (0.50-2.70) | 0.762 | 0.99 (0.41-2.36) | 0.973 | HIF1A rs1154965 | CC | 91 (56-154.5) | | 56 (63.6) | 32 (36.4) | Reference | | Reference | | CT+TT | 79 (54.5-180) | 0.666 | 9 (69.2) | 4 (30.8) | 0.78 (0.22-2.73) | 0.695 | 0.87 (0.24-3.13) | 0.827 |
|
|
Adj: adjusted for age; CI: confidence interval; NT-proBNP: N-terminal pro B-type natriuretic peptide; OR: odds ratio.
|