Clinicopathological and Prognostic Characteristics of CD276 (B7-H3) Expression in Adrenocortical Carcinoma

Table 2

Univariate and multivariate Cox analysis of CD276 expression.

	Univariate analysis			Multivariate analysis
Variables	Hazard ratio	95% CI		Hazard ratio	95% CI
OS
Gender (male)	0.82	0.39-1.73	0.601
Age (≥65)	1.37	0.52-3.57	0.522
Hormone secretion (yes)	0.76	0.37-1.55	0.445
Laterality (right)	0.91	0.45-1.86	0.796
Tumor size (≥7.5)	0.76	0.38-1.52	0.431
T stage (T3+T4)	1.14	0.52-2.48	0.741
N stage (N1)	0.76	0.27-2.16	0.605
Stage (III+IV)	1.06	0.5-2.25	0.88
R status (R1/2/X)	1.22	0.6-2.47	0.589
Ki67 index (high)	3.17	1.53-6.56	0.002	3.16	1.52-6.61	0.002
CD276 tumor cells (high)	2.83	1.29-6.17	0.009	2.8	1.28-6.15	0.01
CD276 membrane (high)	1.4	0.54-3.66	0.488
CD276 vascular (positive)	1.26	0.63-2.53	0.517
DFS
Gender (male)	0.64	0.26-1.54	0.317
Age (≥65)	0.55	0.13-2.36	0.424
Hormone secretion (yes)	1.07	0.47-2.41	0.873
Laterality (right)	1.6	0.71-3.6	0.253
Tumor size (≥7.5)	0.8	0.36-1.81	0.596
T stage (T3+T4)	1.62	0.69-3.81	0.272
N stage (N1)	0.43	0.1-1.83	0.252
Stage (III+IV)	1.2	0.51-2.83	0.678
R status (R1/2/X)	3.27	1.44-7.39	0.005	2.8	1.23-6.39	0.014
Ki67 index (high)	0.85	0.35-2.06	0.72
CD276 tumor cells (high)	8.13	2.71-24.4	<0.001	7.52	2.47-22.91	<0.001
CD276 membrane (high)	0.84	0.31-2.28	0.736
CD276 vascular (positive)	1.15	0.52-2.56	0.733