Upregulation of FEN1 Is Associated with the Tumor Progression and Prognosis of Hepatocellular Carcinoma

Table 4

Univariate and multivariate analysis of FEN1 associated with OS and RFS in TCGA HCC cohort.

			Univariate analysis			Multivariate analysis
		OS (%)	HR	95% CI	value	HR	95% CI	value
Univariate and multivariate analyses of overall survival in HCC patients ()
Age	<Medium ()	116 (72.1%)	0.822	0.580–1.165	0.270
	≥Medium ()	112(67.1%)
Gender	Female ()	67 (63.8%)	1.117	0.936-1.334	0.220
	Male ()	161(72.2%)
Race	Others ()	122 (72.2%)	1.454	0.800-2.642	0.220
	White ()	106 (66.7%)
TNM stage	Stage I/II ()	187 (76.3%)	2.483	1.713-3.600	<0.001	2.271	1.544-3.339	<0.001
	Stage III/IV ()	41 (49.4%)
AFP expression	Low ()	115 (73.3%)	0.859	0.608-1.215	0.391
	High ()	113 (66.1%)
FEN1 expression	Low ()	124 (76.1%)	1.606	1.133-2.277	0.008	1.378	0.935-2.029	0.105
	High ()	104 (63.0%)
Univariate and multivariate analyses of relapse-free survival in HCC patients ()
Age	<Medium ()	116 (72.1%)	0.965	0.845-1.102	0.601
	≥Medium ()	112 (67.1%)
Gender	Female ()	67 (63.8%)	1.053	0.916-1.209	0.468
	Male ()	161(72.2%)
Race	Others ()	122 (72.2%)	0.865	0.638-1.174	0.352
	White ()	106 (66.7%)
TNM stage	Stage I/II ()	187 (76.3%)	2.066	1.538-2.775	<0.001	1.883	1.388-2.556	<0.001
	Stage III/IV ()	41 (49.4%)
AFP expression	Low ()	115 (73.3%)	0.846	0.650-1.102	0.215
	High ()	113 (66.1%)
FEN1 expression	Low ()	124 (76.1%)	1.593	1.221-2.078	0.001	1.387	1.043-1.845	0.025
	High ()	104 (63.0%)