Research Article
Upregulation of FEN1 Is Associated with the Tumor Progression and Prognosis of Hepatocellular Carcinoma
Table 4
Univariate and multivariate analysis of FEN1 associated with OS and RFS in TCGA HCC cohort.
| | | | Univariate analysis | Multivariate analysis | | OS (%) | HR | 95% CI | value | HR | 95% CI | value |
| Univariate and multivariate analyses of overall survival in HCC patients () | Age | <Medium () | 116 (72.1%) | 0.822 | 0.580–1.165 | 0.270 | | | | ≥Medium () | 112(67.1%) | Gender | Female () | 67 (63.8%) | 1.117 | 0.936-1.334 | 0.220 | | | | Male () | 161(72.2%) | Race | Others () | 122 (72.2%) | 1.454 | 0.800-2.642 | 0.220 | | | | White () | 106 (66.7%) | TNM stage | Stage I/II () | 187 (76.3%) | 2.483 | 1.713-3.600 | <0.001 | 2.271 | 1.544-3.339 | <0.001 | Stage III/IV () | 41 (49.4%) | AFP expression | Low () | 115 (73.3%) | 0.859 | 0.608-1.215 | 0.391 | | | | High () | 113 (66.1%) | FEN1 expression | Low () | 124 (76.1%) | 1.606 | 1.133-2.277 | 0.008 | 1.378 | 0.935-2.029 | 0.105 | High () | 104 (63.0%) |
| Univariate and multivariate analyses of relapse-free survival in HCC patients () | Age | <Medium () | 116 (72.1%) | 0.965 | 0.845-1.102 | 0.601 | | | | ≥Medium () | 112 (67.1%) | Gender | Female () | 67 (63.8%) | 1.053 | 0.916-1.209 | 0.468 | | | | Male () | 161(72.2%) | Race | Others () | 122 (72.2%) | 0.865 | 0.638-1.174 | 0.352 | | | | White () | 106 (66.7%) | TNM stage | Stage I/II () | 187 (76.3%) | 2.066 | 1.538-2.775 | <0.001 | 1.883 | 1.388-2.556 | <0.001 | Stage III/IV () | 41 (49.4%) | AFP expression | Low () | 115 (73.3%) | 0.846 | 0.650-1.102 | 0.215 | | | | High () | 113 (66.1%) | FEN1 expression | Low () | 124 (76.1%) | 1.593 | 1.221-2.078 | 0.001 | 1.387 | 1.043-1.845 | 0.025 | High () | 104 (63.0%) |
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