Upregulation of FEN1 Is Associated with the Tumor Progression and Prognosis of Hepatocellular Carcinoma

Figure 3

FEN1 protein is significantly upregulated in our HCC TMA cohort. (a) Representative FEN1 and immunohistochemical staining patterns with different staining scores in HCC tissues. (b) Representative FEN1 histologic scoring in HCC tissues and paired nontumor samples. (c) Distribution of FEN1 immunohistochemical staining scores in HCC tissues according to liver cirrhosis, tumor multiplicity, maximal tumor size, venous invasion, pathologic TNM stage, and AFP level. (d) Forest plot depicting correlations between the indicated clinical criteria and the FEN1 staining scores. (e) The overall survival analysis of FEN1 expression in the HCC TMA cohort. (f) The overall survival analysis between different degrees of FEN1 and different degrees of the TNM stage. FEN1: flap endonuclease 1; HCC: hepatocellular carcinoma; TMA: tissue microarrays; HE: hematoxylin-eosin staining; TNM: tumor, lymph node, metastasis.

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