Research Article
Bioinformatics Analysis of Potential Key Genes in Trastuzumab-Resistant Gastric Cancer
Table 3
Overall survival analysis based on the expression of the hub genes.
| Gene name | ID | OS (all) | OS (HER2-) | OS (HER2+) | HR (95% CI) | value | HR (95% CI) | value | HR (95% CI) | value |
| ERBB2 | 210930_s_at | 1.37 (1.14-1.65) | 0.00088 | 1.33 (1.06-1.66) | 0.013 | 0.73 (0.55-0.97) | 0.027 | VIM | 201426_s_at | 1.29 (1.09-1.53) | 0.0031 | 1.52 (1.21-1.9) | 0.00027 | 1.4 (1.01-1.92) | 0.04 | EGR1 | 201694_s_at | 0.63 (0.52-0.76) | 8.5 | 0.78 (0.61-1) | 0.052 | 0.6 (0.46-0.79) | 0.00023 | PSMB8 | 209040_s_at | 0.45 (0.37-0.56) | 6.6 | 0.39 (0.3-0.5) | 1.7 | 0.62 (0.46-0.85) | 0.0024 | IFI44 | 214059_at | 1.46 (1.22-1.74) | 0.000028 | 1.39 (1.1-1.75) | 0.0056 | 1.67 (1.28-2.19) | 0.00015 | IFI44L | 204439_at | 0.85 (0.71-1.03) | 0.1 | 0.75 (0.58-0.98) | 0.037 | 1.59 (1.16-2.19) | 0.0037 | IFIT2 | 217502_at | 1.26 (1.04-1.53) | 0.018 | 0.84 (0.67-1.05) | 0.12 | 1.7 (1.24-2.33) | 0.00075 | IFIT3 | 204747_at | 1.14 (0.95-1.36) | 0.16 | 0.75 (0.59-0.95) | 0.017 | 1.54 (1.15-2.07) | 0.0037 | ISG15 | 205483_s_at | 0.86 (0.71-1.03) | 0.094 | 0.73 (0.56-0.93) | 0.012 | 1.5 (1.1-2.05) | 0.01 | OAS1 | 202869_at | 1.15 (0.97-1.37) | 0.1 | 0.79 (0.63-0.99) | 0.039 | 1.39 (1.07-1.8) | 0.013 | OASL | 210797_s_at | 1.16 (0.98-1.37) | 0.09 | 0.84 (0.67-1.05) | 0.12 | 1.41 (1.04-1.92) | 0.028 | SAMD9 | 219691_at | 0.73 (0.61-0.88) | 0.00065 | 0.57 (0.44-0.74) | 0.00002 | 1.23 (0.94-1.6) | 0.14 | BST2 | 201641_at | 0.7 (0.58-0.85) | 0.00027 | 0.55 (0.42-0.7) | 1.9 | 1.28 (0.94-1.73) | 0.12 | IFI27 | 202411_at | 0.7 (0.59-0.84) | 0.000096 | 0.58 (0.46-0.73) | 1.8 | 0.85 (0.63-1.13) | 0.26 | IFIT1 | 203153_at | 0.73 (0.61-0.87) | 0.00061 | 0.63 (0.49-0.81) | 0.00025 | 1.23 (0.95-1.6) | 0.12 | IFITM3 | 212203x_at | 1.09 (0.91-1.29) | 0.36 | 0.89 (0.71-1.12) | 0.32 | 1.27 (0.96-1.69) | 0.096 | MX1 | 202086_at | 1.27 (1.05-1.54) | 0.015 | 1.15 (0.9-1.47) | 0.26 | 1.32 (0.99-1.76) | 0.056 | OAS2 | 204972_at | 0.91 (0.77-1.08) | 0.3 | 0.77 (0.61-0.96) | 0.021 | 1.25 (0.93-1.67) | 0.13 |
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Abbreviation: OS: overall survival; HER2-: human epidermal growth factor receptor-2 negative; HER2+: human epidermal growth factor receptor-2 positive.
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