A Specific Circulating MicroRNA Cluster Is Associated to Late Differential Cardiac Response to Doxorubicin-Induced Cardiotoxicity In Vivo

Figure 2

Differential cardiac response to doxorubicin treatment. Unsupervised clustering based on cardiac functional parameters at T0 (a) and T42 (b). At T0, all animals were grouped together. At T42, a cluster of drug-treated animals was clearly separated (Tox) from those unaffected (NoTox) by doxorubicin and CTRLs. Cardiac functional parameters: LVEF: left ventricular ejection fraction; LVFS: left ventricular fractional shortening; LVDD: left ventricular diastolic diameter; LVSD: left ventricular systolic diameter; LVDV: left ventricular diastolic volume; LVSV: left ventricular systolic volume.