Evaluation of Prognostic and Predictive Significance of Circulating MicroRNAs in Ovarian Cancer Patients

Table 3

Cox regression analysis shows the variables significantly associated with prognosis. Variables not significant are left out of the final model except from miR-1274A and miR-141. In the full model, the variables including age, FIGO stage, grade, residual disease, and type of treatment were included in addition to the 4 microRNAs.

Variable	value	HR	95% CI for HR
mir_1274B	0.085	0.846	0.70–1.02
miR_200b	0.006	0.798	0.68–0.94
miR-141	0.153	0.914	0.81–1.03
FIGO stage
Stage I (reference)	0.08
Stage II	0.911	1.073	0.31–3.68
Stage III	0.352	1.564	0.61–4.01
stage IV	0.036	3.368	1.08–10.49
Residual disease
No residual disease (reference)	<0.001
Residual 0-1 cm	0.853	0.863	0.18–4.13
Residual > 1 cm	<0.001	3.005	1.70–5.31
Inoperable	<0.001	3.259	1.76–6.04
Treated with bevacizumab versus chemotherapy	<0.001	0.373	0.23–0.60