Evaluation of Prognostic and Predictive Significance of Circulating MicroRNAs in Ovarian Cancer Patients

Table 2

The levels of 6 identified microRNAs were investigated for association with survival irrespective of treatment group, in the discovery set and in the validation set. False discovery rate (FDR) is shown in the discovery set, and the values from Student’s -test are applied in the validation set. The prognostic value of the six microRNAs was also tested in all the histology types combined, in addition to high-grade serous samples separately. NA = not applicable and NS = not significant.

	⁢Discovery set			⁢Validation set
Histology	⁢All histologies combined		High-grade serous	⁢All histologies combined		High-grade serous
MicroRNA	SAM analysis	Log-rank test	Log-rank test	Student’s; -test	Log-rank test	Log-rank test
	FDR	value	value	value	value	value
miR-1274A	<0.001	0.002	0.031	0.61	0.48	0.012
miR-141	<0.001	0.011	0.111	0.012	0.013	0.099
miR-200b	<0.001	0.024	0.01	0.014	0.003	0.288
miR-200c	<0.001	0.001	0.007	0.092	0.305	0.17
miR-520d-3p	<0.001	NS	NA	0.343	NA	NA
miR-520c-3p	<0.001	NS	NA	0.742	NA	NA