Review Article
Interleukin-6-174G/C Polymorphism Contributes to Periodontitis Susceptibility: An Updated Meta-Analysis of 21 Case-Control Studies
Table 2
Overall and subgroup meta-analyses.
| Genetic models and subgroups | Number of studies | Association | Heterogeneity | Model of meta-analysis | Publication bias () | OR (95% CI) | P value | (%) | P value |
| C VS G | 19 | 0.979 (0.714–1.344) | 0.897 | 87.3 | 0.000 | Random | 0.517 | HWE fulfilled | 12 | 0.770 (0.558–1.064) | 0.114 | 72.4 | 0.000 | Random | Caucasian | 8 | 0.957 (0.670–1.366) | 0.807 | 80.0 | 0.000 | Random | Brazilian | 6 | 0.648 (0.497–0.845) | 0.001 | 49.0 | 0.081 | Fixed | Asian | 4 | 1.881 (0.667–5.305) | 0.233 | 93.7 | 0.000 | Random | Indian | 1 | NA | NA | NA | NA | NA | No smoke | 7 | 1.032 (0.463–2.296) | 0.939 | 94.7 | 0.000 | Random | Matched gender ratio | 10 | 1.161 (0.869–1.552) | 0.311 | 73.2 | 0.000 | Random | Community control | 8 | 1.040 (0.760–1.424) | 0.805 | 10.3 | 0.001 | Random | Caucasian (HWE fulfilled) | 4 | 0.814 (0.559–1.184) | 0.281 | 73.6 | 0.281 | Random |
| GC VS GG | 18 | 0.897 (0.516–1.558) | 0.699 | 89.8 | 0.000 | Random | 0.035 | HWE fulfilled | 11 | 0.690 (0.560–0.849) | 0.000 | 27.3 | 0.184 | Fixed | Caucasian | 8 | 1.066 (0.543–2.093) | 0.852 | 84.9 | 0.000 | Random | Brazilian | 5 | 0.621 (0.441–0.876) | 0.007 | 6.1 | 0.372 | Fixed | Asian | 4 | 1.673 (0.360–7.783) | 0.512 | 89.1 | 0.000 | Random | Indian | 1 | NA | NA | NA | NA | NA | No smoke | 5 | 0.663 (0.506–0.871) | 0.003 | 25.2 | 0.245 | Fixed | Matched gender ratio | 10 | 1.211 (0.574–2.555) | 0.615 | 91.4 | 0.000 | Random | Community control | 8 | 1.120 (0.445–2.820) | 0.809 | 93.0 | 0.000 | Random | Caucasian in HWE | 4 | 0.752 (0.577–0.980) | 0.035 | 55.7 | 0.080 | Fixed |
| CC + GC VS GG | 19 | 0.907 (0.616–1.335) | 0.621 | 83.9 | 0.000 | Random | 0.021 | HWE fulfilled | 12 | 0.690 (0.568–0.838) | 0.000 | 44.3 | 0.049 | Fixed | Caucasian | 9 | 0.974 (0.640–1.482) | 0.902 | 72.4 | 0.000 | Random | Brazilian | 5 | 0.649 (0.470–0.896) | 0.009 | 27.8 | 0.236 | Fixed | Asian | 4 | 2.692 (2.160–3.354) | 0.000 | 0.0 | 0.830 | Fixed | Indian | 1 | NA | NA | NA | NA | NA | No smoke | 6 | 0.611 (0.274–1.361) | 0.228 | 88.5 | 0.000 | Random | Matched gender ratio | 11 | 1.034 (0.652–1.641) | 0.886 | 81.0 | 0.000 | Random | Community control | 9 | 1.801 (0.575–1.018) | 0.952 | 85.2 | 0.000 | Random | Caucasian in HWE | 4 | 0.737 (0.576–0.944) | 0.016 | 60.8 | 0.054 | Fixed |
| CC VS GG + GC | 17 | 0.846 (0.404–1.772) | 0.657 | 92.5 | 0.000 | Random | 0.762 | HWE fulfilled | 10 | 0.896 (0.361–2.226) | 0.813 | 86.5 | 0.000 | Random | Caucasian | 9 | 1.127 (0.495–2.565) | 0.775 | 89.0 | 0.000 | Random | Brazilian | 5 | 0.834 (0.454–1.532) | 0.559 | 40.0 | 0.155 | Fixed | Asian | 2 | 0.996 (0.032–31.216) | 0.998 | 99.2 | 0.000 | Random | Indian | 1 | NA | NA | NA | NA | NA | No smoke | 6 | 0.625 (0.157–2.488) | 0.505 | 93.2 | 0.000 | Random | Matched gender ratio | 12 | 0.888 (0.357–2.214) | 0.799 | 91.8 | 0.000 | Random | Community control | 6 | 1.009 (0.230–4.436) | 0.990 | 95.0 | 0.000 | Random | Caucasian in HWE | 4 | 1.788 (0.398–8.028) | 0.448 | 94.2 | 0.000 | Random |
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NA = not available.
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