Review Article
Interleukin-6-174G/C Polymorphism Contributes to Periodontitis Susceptibility: An Updated Meta-Analysis of 21 Case-Control Studies
Table 1
Characteristics of the included studies.
| | Author and Year | Country (ethnicity) | Type | Group size
(case/control) | Smoke status | Control | Gender | Quality | HWE |
| | Babel et al. 2006 [28] | Germany (Caucasian) | Case-control | 124/116 | Unknown | HC | Matched | 7/9 | Fulfilled | | Brett et al. 2005 [14] | UK (Caucasian) | Case-control | 106/99 | Mixed | CC | Matched | 7/9 | 0.000 | | Casado et al. 2013 [15] | Brazil (Brazilian) | Case-control | 43/60 | Unknown | HC | Not matched | 6/9 | 0.805 | | Costa et al. 2010 [16] | Brazil (Brazilian) | Case-control | 38/27 | No smoke | CC | Not matched | 7/9 | 1.000 | | Dosseva-Panova et al. 2015 [17] | Bulgaria (Caucasian) | Case-control | 30/10 | Unknown | HC | Not matched | 5/9 | 0.035 | | Fan et al. 2011 [18] | China (Asian) | Case-control | 178/130 | Mixed | CC | Not matched | 8/9 | 0.964 | | Gabriela Teixeira et al. 2014 [21] | Brazil (Brazilian) | Case-control | 134/196 | Mixed | CC | Matched | 7/9 | 0.821 | | Holla et al. 2004 [29] | Czech (Caucasian) | Case-control | 148/107 | Mixed | CC | Matched | 8/9 | 0.783 | | Ianni et al. 2013 [5] | Italy (Caucasian) | Case-control | 77/278 | No smoke | CC | Not matched | 7/9 | 0.984 | | Jansson et al. 2006 [30] | Sweden (Caucasian) | Case-control | 19/31 | Unknown | HC | Matched | 6/9 | 0.025 | | Kalburgi et al. 2010 [31] | India (Indian) | Case-control | 15/15 | No smoke | HC | Matched | 7/9 | 0.217 | | Loo et al. 2012 [32] | China (Asian) | Case-control | 440/850 | Unknown | CC | Matched | 8/9 | 0.000 | | Moreira et al. 2007 [33] | Brazil (Brazilian) | Case-control | 155/54 | Mixed | HC | Matched | 6/9 | 0.106 | | Scapoli et al. 2012 [34] | Italy (Caucasian) | Case-control | 177/117 | Mixed | HC | Matched | 5/9 | 0.000 | | Scapoli et al. 2015 [22] | Italy (Caucasian) | Case-control | 284/211 | No smoke | HC | Not matched | 6/9 | 0.133 | | Stefani et al. 2013 [24] | Brazil (Brazilian) | Case-control | 21/21 | No smoke | HC | Matched | 6/9 | 0.760 | | Tervonen et al. 2007 [35] | Finland (Caucasian) | Case-control | 51/178 | Mixed | CC | Matched | 8/9 | NA | | Tian et al. 2013 [25] | China (Asian) | Case-control | 122/532 | No smoke | HC | Not matched | 6/9 | 0.000 | | Trevilatto et al. 2003 [36, 37] | Brazil (Caucasian) | Case-control | 48/36 | Unknown | HC | Matched | 7/9 | 0.142 | | Trindade et al. 2013 [26] | Brazil (Brazilian) | Case-control | 49/60 | No smoke | HC | Not matched | 6/9 | Fulfilled | | Xiao et al. 2009 [38] | China (Asian) | Case-control | 157/132 | Mixed | CC | Not matched | 7/9 | 0.502 |
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HC = hospital control and CC = community control.
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