Identification of Differentially Expressed Genes Associated with Prognosis of B Acute Lymphoblastic Leukemia
Table 4
Survival analysis and OR values for differentially expressed genes between B-ALL relapsed patients and event-free cases.
Gene-time (cutoff value)
Group±
/events†
Survival time (mean, months)
Standard error
95% CI
value
OR
95% CI
value
FLT3-T1 (0.1719)
1
38/7
31.13
1.803
27.6–34.7
0.012*
3.73
1.3–10.72
0.024*
2
35/16
25.003
2.679
19.7–30.3
IL2RA-T1 (1.173)
1
38/7
31.05
1.829
27.5–34.6
0.012*
3.73
1.3–10.72
0.024*
2
35/16
24.71
2.745
19.3–30.1
FLT3-T2 (−0.4638)
1
32/4
31.47
1.901
27.7–35.2
0.004*
6.05
1.8–20.36
0.005*
2
41/19
25.19
2.398
20.5–29.9
FLT3-T3 (−0.149)
1
35/5
34.83
1.928
31.1–38.6
0.002*
5.4
1.7–16.9
0.005*
2
38/18
23.02
2.309
18.5–27.6
DEFA1-T3 (3.041)
1
43/8
30.84
1.775
27.4–34.3
0.006*
4.38
1.5–12.5
0.01*
2
30/15
24.13
2.825
18.6–29.7
IL2RA-T1-children (1.220)
1
25/3
32.76
2.153
28.5–37.0
0.062
4.03
0.98–16.6
0.088
2
30/10
28.57
2.857
23.0–34.2
FLT3-T2-children (−0.475)
1
24/1
33.83
—
—
0.003*
14.53
1.7–122.1
0.008*
2
31/12
27.04
2.844
21.5–32.6
FLT3-T3-adults (−0.304)
1
9/3
24.87
4.128
16.7–33.0
0.038*
27
2.0–368.4
0.013*
2
9/7
11.44
1.061
9.4–13.5
SORT1-T3-Adults (5.007)
1
7/0
—
—
—
<0.001*
14
1.1–172.6
0.05
2
10/10
11
1.193
8.7–13.3
FLT3-T2-standard risk (−0.464)
1
18/0
—
—
—
<0.001*
Undetermined
—
<0.001*
2
16/8
22.51
3.625
15.4–29.6
DEFA1-T3-high risk (3.041)
1
26/5
27.71
2.780
22.3–33.2
0.081
4.0
1.02–15.72
0.089
2
28/10
22.79
3.627
15.7–29.9
Group 1 represents B-ALL cases with a log 2 of expression level ≤ cutoff value (for the indicated gene); in the group 2 those patients with their log 2 of expression level > cutoff for the indicated gene were included. value for survival curves differences. value for OR test. †Event indicates relapse or death. *Statistical significance.
