Reduced Histone H3 Acetylation in CD4⁺ T Lymphocytes: Potential Mechanism of Latent Autoimmune Diabetes in Adults

Table 3

Correlation analysis of global histone H3/H4 acetylation in CD4⁺ T lymphocytes from LADA patients.

	H4 acetylation		H3 acetylation
	( = 28)		( = 28)
	FBS	0.015	0.860	−0.520	0.232
PBS	0.076	0.766	−0.159	0.553
HbA1c	−0.356	0.085	−0.623	0.021
FCP	0.445	0.079	0.117	0.843
PCP	0.242	0.525	0.154	0.762
Age	0.432	0.275	0.362	0.254
Duration of the disease	−0.153	0.161	−0.186	0.108
Diabetic nephropathy	−0.139	0.212	−0.264	0.279
CVD	−0.217	0.183	−0.287	0.163

LADA patients’ CD4⁺ T lymphocytes H3 acetylation were not related with fasting blood glucose (FBS), postprandial blood glucose (PBS), fasting C-peptide (FCP), postprandial C-peptide (PCP), age, duration of the disease, diabetic nephropathy, and cardiovascular disease (CVD), but associated with glycosylated hemoglobin (HbA1c). H4 acetylation was not related to any of these factors.