Research Article
Reduced Histone H3 Acetylation in CD4+ T Lymphocytes: Potential Mechanism of Latent Autoimmune Diabetes in Adults
Table 1
Subject characteristics.
| | Parameters | LADA patients () | Control subjects () | value | LADA patients | | Complication free | With complication | value | | ( = 11) | ( = 17) |
| | Gender (male%) | 46.4% | 46.4% | 1.0 | 45.6% | 47.1% | 0.79 | | Age (years) | 43.0 ± 6.9 | 40.1 ± 6.3 | 0.82 | 39.3 ± 5.7 | 45.2 ± 6.9 | 0.25 | | BMI (kg/m2) | 23.8 ± 3.2 | 23.2 ± 3.4 | 0.79 | 22.0 ± 1.1 | 24.8 ± 1.3 | 0.39 | | Diabetes duration (years) | 9.7 ± 3.8 | 0 | <0.01 | 6.8 ± 3.4 | 11.5 ± 4.7 | 0.03 | | HbA1c (%) | 9.6 ± 2.5 | 5.1 ± 1.3 | <0.01 | 7.8 ± 2.3 | 10.8 ± 3.1 | 0.04 | | FCP (nmol/L) | 0.42 ± 0.26 | — | — | 0.57 ± 0.23 | 0.32 ± 0.28 | 0.12 | | Low FCP | 8/28 (28.6%) | — | — | 2/11 (18.2%) | 6/17 (35.3%) | — | | High titer GADA | (9/28) 30.0% | — | — | 3/11 (27.3%) | 6/17 (35.3%) | — | | Low titer GADA | (19/28) 70.0% | — | — | 8/11 (72.7%) | 11/17 (64.7%) | — | | Total cholesterol (mmol/L) | 4.2 ± 0.9 | 4.3 ± 0.8 | 0.53 | 4.1 ± 0.6 | 4.3 ± 1.1 | 0.28 | | Triglyceride (mmol/L) | 1.7 ± 0.5 | 1.8 ± 0.6 | 0.65 | 1.6 ± 0.4 | 1.7 ± 0.7 | 0.49 | | HDL cholesterol (mmol/L) | 1.0 ± 0.3 | 1.2 ± 0.4 | 0.43 | 1.1 ± 0.3 | 0.9 ± 0.2 | 0.26 | | LDL cholesterol (mmol/L) | 2.8 ± 0.6 | 2.9 ± 0.8 | 0.72 | 2.6 ± 0.7 | 2.9 ± 0.8 | 0.21 | | Serum creatine (μmol/L) | 102 ± 19.2 | 80 ± 11.2 | 0.09 | 90 ± 12.8 | 109 ± 16.7 | 0.12 | | Nephropathy () | 8 | 0 | — | 0 | 8 | — | | Retinopathy () | 5 | 0 | — | 0 | 5 | — | | Neuropathy () | 8 | 0 | — | 0 | 8 | — | | Macrovascular complications | 3 | 0 | — | 0 | 3 | — |
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: number of subjects; BMI: body mass index; FBS: fasting glucose; PBS: postprandial glucose; HbA1c: glycated hemoglobin; FCP: fasting C-peptide; PCP: postprandial C-peptide; HDL: high-density lipoprotein; LDL: low-density lipoprotein; GADA: glutamic acid decarboxylase antibody.
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