Reduced Histone H3 Acetylation in CD4⁺ T Lymphocytes: Potential Mechanism of Latent Autoimmune Diabetes in Adults

Figure 4

Association of complication and HbA1c with the expression of histone acetyltransferases and deacetylases in CD4⁺ T lymphocytes from LADA patients. (a) Relative mRNA levels of histone acetyltransferase (CREBBP) in CD4⁺ T lymphocytes from patients with LADA, LADA patients with complications (LADAc, ) versus LADA patients without complications (LADAnc, ), . (b) Relative mRNA levels of histone deacetylases (HDAC1 and HDAC7) in CD4⁺ T lymphocytes from patients with LADA, LADA patients with complications (LADAc) versus LADA patients without complications (LADAnc), . (c) Relative mRNA levels of histone acetyltransferases (CREBBP) in CD4⁺ T lymphocytes from patients with LADA, LADA patients with HbA1c > 7% () versus LADA patients with patients HbA1c < 7% (), . (d) Relative mRNA levels of histone deacetylases (HDAC1 and HDAC7) in CD4⁺ T lymphocytes from LADA patients, LADA patients with HbA1c > 7% versus LADA patients with patients HbA1c < 7%, .

(a)

(b)

(c)

(d)