Good correlation with disability progression and cognitive dysfunction: rate of thalamic atrophy in MS subjects was correlated with changes in EDSS; cerebellar cortical atrophy was indicated among the predictive parameters of progression in those RR MS patients who converted to the SP phase
GM magnetization transfer ratio histogram peak height and average lesion magnetization transfer ratio percentage change after 12 months were independent predictors of disability worsening at 8 years
Average GM mean diffusivity, identified patients with high risk of disease progression over the following 5 years; change in fractional anisotropy of normal appearing GM and disease duration were independent predictors of EDSS change